Column objects returned by Columns.Default and Column objects in the column or row headers do not have a label.
FarPoint.Win.Spread.Column col;
col = fpSpread1.ActiveSheet.Columns[0];
col.Label = "Column 1";
Dim col As FarPoint.Win.Spread.Column col = fpSpread1.ActiveSheet.Columns(0) col.Label = "Column 1"